Understanding the brain mechanisms behind involuntary movements caused by antipsychotic medications
Striatal Microcircuit Mechanisms of Tardive Dyskinesia
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11010405
This study is looking into what causes tardive dyskinesia, a condition that can happen after taking certain medications for a long time, and it aims to find out how specific brain receptors are involved, which could help improve treatments for people dealing with this issue.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11010405 on ClinicalTrials.gov |
What this research studies
This research investigates the causes of tardive dyskinesia (TD), a condition characterized by involuntary movements often resulting from long-term use of antipsychotic medications. By utilizing a mouse model, the study aims to identify the specific dopamine receptors involved in the development and persistence of TD. Researchers will employ advanced genetic and physiological techniques to measure dopamine activity in the brain, providing insights into how these medications affect movement control. The findings could lead to better treatment strategies for patients experiencing TD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been treated with antipsychotic medications and are experiencing symptoms of tardive dyskinesia.
Not a fit: Patients who have not been treated with antipsychotic medications or do not exhibit symptoms of tardive dyskinesia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent or mitigate the involuntary movements associated with tardive dyskinesia.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of tardive dyskinesia, but this study aims to provide novel insights using advanced methodologies.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NELSON, ALEXANDRA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: NELSON, ALEXANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.