Understanding the brain mechanisms behind involuntary movements caused by antipsychotic medications
Official title: Striatal Microcircuit Mechanisms of Tardive Dyskinesia
Funded at University of California, San Francisco · NIH-11010405 · Data updated 2026-11-12
This study is looking into what causes tardive dyskinesia, a condition that can happen after taking certain medications for a long time, and it aims to find out how specific brain receptors are involved, which could help improve treatments for people dealing with this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $358,088 |
| NIH project number | 5R01NS131276-03 |
| Project ID | NIH-11010405 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been treated with antipsychotic medications and are experiencing symptoms of tardive dyskinesia.
✕Less likely to help
Patients who have not been treated with antipsychotic medications or do not exhibit symptoms of tardive dyskinesia may not benefit from this research.
What this research studies
This research investigates the causes of tardive dyskinesia (TD), a condition characterized by involuntary movements often resulting from long-term use of antipsychotic medications. By utilizing a mouse model, the study aims to identify the specific dopamine receptors involved in the development and persistence of TD. Researchers will employ advanced genetic and physiological techniques to measure dopamine activity in the brain, providing insights into how these medications affect movement control. The findings could lead to better treatment strategies for patients experiencing TD.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent or mitigate the involuntary movements associated with tardive dyskinesia.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of tardive dyskinesia, but this study aims to provide novel insights using advanced methodologies.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Nelson, Alexandra — University of California, San Francisco
- Study coordinator: Nelson, Alexandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.