Understanding the brain mechanisms behind bladder pain syndrome
CNS Mechanisms of IC/BPS
This study is looking at how certain brain cells might be linked to the pain and emotional struggles that come with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) in women, with the hope of finding better treatments for those who suffer from this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11136869 on NIH RePORTER |
What this research studies
This research investigates the underlying brain mechanisms involved in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS), a painful condition affecting many women. The study focuses on how specific neurons in the brain's central amygdala may influence bladder pain and related emotional issues like anxiety and depression. By utilizing advanced techniques such as RNA sequencing and spatial transcriptomics, researchers aim to identify how these neurons interact and contribute to the symptoms of IC/BPS. This could lead to new insights into more effective treatments for patients suffering from this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with Interstitial Cystitis/Bladder Pain Syndrome, particularly those experiencing significant pain and emotional distress.
Not a fit: Patients without a diagnosis of IC/BPS or those whose symptoms are not related to bladder pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from bladder pain syndrome and associated mental health issues.
How similar studies have performed: Previous research has shown promise in understanding the brain mechanisms related to pain and emotional disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Gereau, Robert W — Washington University
- Study coordinator: Gereau, Robert W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.