Understanding the brain factors related to alcohol use disorder
Multi 'Omics Integration and Neurobiological Signatures of Alcohol Use Disorder
This study is looking at how our genes might affect alcohol use disorder by examining brain tissue from people with the condition, helping us understand why some individuals may struggle with alcohol more than others.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project ID | NIH-10678775 on NIH RePORTER |
What this research studies
This research aims to uncover the neurobiological factors that contribute to alcohol use disorder (AUD) by examining differences in gene expression and DNA methylation in specific brain regions. Researchers will analyze brain tissues from individuals with AUD to identify genetic variants associated with the disorder. The study employs advanced genome-wide testing methods to explore how these genetic factors influence alcohol consumption and the risk of developing AUD. By mapping these genetic differences, the research seeks to enhance our understanding of the biological mechanisms underlying AUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with alcohol use disorder.
Not a fit: Patients who do not have alcohol use disorder or are under the age of 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for individuals struggling with alcohol use disorder.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to alcohol use, making this approach a promising avenue for further exploration.
Where this research is happening
Research Triangle Park, United States
- Research Triangle Institute — Research Triangle Park, United States (Active)
Researchers
- Principal investigator: Hancock, Dana B — Research Triangle Institute
- Study coordinator: Hancock, Dana B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.