Understanding the brain differences in PTSD and depression
Site 3/3, Understanding PTSD through Postmortem Targeted Brain Multiomics
['FUNDING_R01'] · MCLEAN HOSPITAL · NIH-11130516
This study is looking at the differences in brain tissue from people with PTSD and depression to better understand how trauma affects the brain, which could help improve treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MCLEAN HOSPITAL (nih funded) |
| Locations | 1 site (BELMONT, UNITED STATES) |
| Trial ID | NIH-11130516 on ClinicalTrials.gov |
What this research studies
This research investigates the neurobiological differences between individuals with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) by analyzing postmortem brain tissues. The study involves a collaborative effort across three sites, focusing on specific brain regions known to be associated with PTSD risk. By examining genetic and molecular changes in the brains of individuals diagnosed with PTSD, MDD, and neurotypical controls, the research aims to uncover the underlying mechanisms that contribute to these disorders. This could provide valuable insights into how trauma affects the brain and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with PTSD or MDD, as well as neurotypical individuals for comparison.
Not a fit: Patients who do not have PTSD, MDD, or related psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals suffering from PTSD and MDD.
How similar studies have performed: Other research has shown success in understanding psychiatric disorders through postmortem brain studies, making this approach promising.
Where this research is happening
BELMONT, UNITED STATES
- MCLEAN HOSPITAL — BELMONT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RESSLER, KERRY J. — MCLEAN HOSPITAL
- Study coordinator: RESSLER, KERRY J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.