Understanding the brain circuits involved in human mood disorders
Official title: Intracranial Investigation of Neural Circuity Underlying Human Mood
Funded at Baylor College of Medicine · NIH-11078260 · Data updated 2026-11-12
This study is looking at how the brain works in people with depression by recording brain activity from patients with epilepsy and those getting treatment for depression that hasn't worked before, hoping to find better ways to help those struggling with mood disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $778,455 |
| NIH project number | 5R01MH130597-03 |
| Project ID | NIH-11078260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include patients with refractory epilepsy and those with treatment-resistant depression who are undergoing deep brain stimulation.
✕Less likely to help
Patients with mild depression or those not undergoing any invasive procedures may not benefit from this research.
What this research studies
This research investigates the neural circuitry underlying mood disorders, particularly depression, by utilizing advanced intracranial recordings from patients with epilepsy and those undergoing deep brain stimulation for treatment-resistant depression. The study aims to overcome limitations of previous research by employing explainable artificial intelligence (XAI) to analyze brain activity and its relationship to behavior. By combining precise measurements with innovative computational methods, the research seeks to provide insights that could lead to improved treatments for mood disorders.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals suffering from depression and related mood disorders.
How similar studies have gone: Previous research has shown promise in using intracranial recordings and AI approaches to understand brain function, suggesting that this study builds on a foundation of successful methodologies.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Sheth, Sameer Anil — Baylor College of Medicine
- Study coordinator: Sheth, Sameer Anil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.