Understanding the brain changes that lead to dystonia in children and adults
Spatial and temporal pathophysiology of developmental dystonia
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11067779
This study is looking at how certain brain changes in young people might lead to dystonia, a condition that causes painful muscle spasms and movement problems, to help find better ways to treat both kids and adults with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11067779 on ClinicalTrials.gov |
What this research studies
This research investigates the development of dystonia, a neurological condition characterized by severe motor difficulties, including painful muscle contractions and tremors. The study focuses on how specific brain circuits and regions evolve during early life and how these changes may contribute to the onset of dystonia. By examining the role of certain genes involved in brain development, the research aims to uncover the mechanisms that lead to this condition, particularly in pediatric patients who currently have limited treatment options. The findings could help improve understanding and treatment strategies for both children and adults affected by dystonia.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults diagnosed with dystonia or those experiencing severe motor difficulties.
Not a fit: Patients with dystonia caused by non-genetic factors or those who do not exhibit significant motor symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic and therapeutic approaches for patients suffering from dystonia.
How similar studies have performed: Previous research has shown promise in understanding the genetic and developmental aspects of dystonia, but this specific approach focusing on early brain development is relatively novel.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SILLITOE, ROY VINCENT — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: SILLITOE, ROY VINCENT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.