Understanding the brain changes that cause muscle spasms in dystonia
Official title: The structural underpinnings of disinhibition in dystonia
Funded at Ut Southwestern Medical Center · NIH-10923910 · Data updated 2026-11-12
This study is looking at how changes in the brain might cause the muscle spasms seen in dystonia, using MRI scans to find out which brain areas are involved, with the hope of discovering new ways to help manage this challenging condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 20, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $193,973 |
| NIH project number | 5K23NS124978-03 |
| Project ID | NIH-10923910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with dystonia, particularly those experiencing severe symptoms or related neurological disorders.
✕Less likely to help
Patients with dystonia who do not have significant structural brain abnormalities may not benefit from this research.
What this research studies
This research investigates the structural changes in the brain that lead to disinhibition, a key factor in the muscle spasms associated with dystonia. Using MRI technology, the study aims to identify specific brain regions that may contribute to these abnormal muscle movements. By exploring the connections between different parts of the brain, the research seeks to uncover new targets for treatment and prevention of dystonia. This could provide valuable insights into how to better manage this debilitating condition.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for individuals suffering from dystonia.
How similar studies have gone: Previous research has shown promise in using MRI to study brain abnormalities in movement disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Waugh, Jeffrey L. — Ut Southwestern Medical Center
- Study coordinator: Waugh, Jeffrey L.
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.