Understanding the brain changes in Alzheimer's disease and related dementias
Neuropathology Core
This study is looking at the different types of protein build-up in the brains of people with Alzheimer's and similar conditions to help understand what causes memory problems and improve how we diagnose these diseases.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10870023 on NIH RePORTER |
What this research studies
This research focuses on identifying and classifying the various protein deposits that accumulate in the brains of individuals with Alzheimer's disease and related dementias. By examining brain tissues from patients who have been monitored over time, researchers aim to uncover the full range of co-existing neuropathological conditions. This involves detailed post-mortem analysis to provide insights into the underlying causes of cognitive decline and to improve diagnostic criteria. The findings will support further studies aimed at understanding these complex disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias who are willing to participate in post-mortem brain examinations.
Not a fit: Patients with non-neurodegenerative cognitive impairments or those who do not have a diagnosis of Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted treatments for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has successfully utilized similar approaches to understand the neuropathology of Alzheimer's disease, indicating a strong foundation for this investigation.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lee, Edward Byung-Ha — University of Pennsylvania
- Study coordinator: Lee, Edward Byung-Ha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.