Understanding the brain changes in a type of dementia called FTLD-tau.
Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes - Diversity Supplement (Antwan Howard)
This study is looking at how certain brain changes are linked to different types of dementia caused by frontotemporal lobar degeneration (FTLD), especially in younger people, to help improve diagnosis and treatment for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10983624 on NIH RePORTER |
What this research studies
This research investigates frontotemporal lobar degeneration (FTLD), a neurodegenerative disease that leads to various dementia syndromes, particularly in younger individuals. By examining postmortem brain specimens, the study aims to clarify the relationship between different dementia symptoms and the underlying brain pathology associated with FTLD-tau. The research focuses on identifying specific brain changes and cellular features related to common forms of FTLD-tau, such as Pick's disease and other tauopathies. This work is crucial for improving diagnosis and treatment options for patients suffering from these complex dementia syndromes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with FTLD-tau-related dementias, particularly those experiencing symptoms of primary progressive aphasia or behavioral variant frontotemporal dementia.
Not a fit: Patients with dementia not related to FTLD-tau or those with other unrelated neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with FTLD-tau-related dementias.
How similar studies have performed: Previous research has shown promise in understanding the pathology of FTLD-tau, but this specific approach is aimed at further elucidating the complexities of the disease.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Gefen, Tamar D — Northwestern University at Chicago
- Study coordinator: Gefen, Tamar D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.