Understanding the Brain and Genes Behind ADHD and Thinking Skills
Leveraging computational strategies to disentangle the genetic and neural underpinnings of ADHD and its associated cognitive systems
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11175469
This project explores how genes and brain activity contribute to ADHD and related thinking challenges in children and adolescents.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11175469 on ClinicalTrials.gov |
What this research studies
We know that thinking difficulties are common in many brain-related conditions, including ADHD, and can affect daily life. However, the exact connection between these thinking challenges and specific conditions like ADHD is still unclear, especially since not all young people with ADHD experience the same difficulties. This project uses advanced computer methods to sort through vast amounts of information, helping us see how different parts of the brain and genetic factors play a role. Our goal is to uncover the shared and distinct biological roots in the brain and genes that link ADHD with these thinking skills. This deeper understanding could lead to better ways to help patients.
Who could benefit from this research
Good fit: This research focuses on understanding ADHD in children and adolescents, particularly those experiencing thinking challenges.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not receive benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of ADHD, potentially guiding the development of more targeted treatments for thinking difficulties in affected individuals.
How similar studies have performed: While previous studies have linked cognition to ADHD risk, this project uses novel computational strategies to disentangle complex genetic and neural factors in a more comprehensive way.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GE, TIAN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: GE, TIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Attention deficit hyperactivity disorder