Understanding the Bone Marrow Environment in Acute Myeloid Leukemia
Targeting Microenvironmental Signals in Myeloid Malignancies
This research looks at how the bone marrow environment helps acute myeloid leukemia (AML) grow, hoping to find new ways to stop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11127746 on NIH RePORTER |
What this research studies
We know that healthy stem cells rely on their surroundings in the bone marrow to grow and thrive. This project explores whether cancer cells, specifically those in acute myeloid leukemia (AML), also use these same signals from their environment to survive and spread. Our goal is to understand how these leukemia cells interact with the bone marrow, especially with cells that form bone, to find new weaknesses we can target. By uncovering these hidden connections, we hope to develop new strategies to overcome treatment resistance in AML.
Who could benefit from this research
Good fit: This foundational research is relevant for patients diagnosed with acute myeloid leukemia (AML) and blast crisis chronic myeloid leukemia (bcCML).
Not a fit: Patients with conditions other than acute myeloid leukemia or blast crisis chronic myeloid leukemia may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for acute myeloid leukemia by targeting the supportive environment that helps cancer cells grow and resist current therapies.
How similar studies have performed: Previous work by this team has shown that interactions between AML cells and blood vessel cells are important for maintaining therapy-resistant leukemia stem cells, suggesting this approach builds on existing insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Bajaj, Jeevisha — University of Rochester
- Study coordinator: Bajaj, Jeevisha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.