Understanding the Body Clock's Role in Cancer and Immune Response
Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10992630
This project explores how our body's natural 24-hour clock influences melanoma growth and how well the immune system fights it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10992630 on ClinicalTrials.gov |
What this research studies
Our bodies have an internal 24-hour clock that affects many processes, including how our cells work and how our immune system responds. When this clock is disrupted, it might play a role in cancer development and how tumors respond to treatments like immunotherapy. This project looks closely at melanoma, a type of skin cancer, to see how differences in the body clock within cancer cells might make them more or less vulnerable to our immune defenses. We are learning how these clock disruptions could lead to faster tumor growth or resistance to current therapies.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit patients with melanoma by uncovering new treatment strategies.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to improve cancer treatments, especially immunotherapies, by targeting the body's internal clock.
How similar studies have performed: While the link between circadian rhythms and cancer is an emerging field, preliminary findings in cell lines and mouse models suggest a significant connection, making this a promising area of novel investigation.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DANG, CHI V. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: DANG, CHI V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.