Understanding the biology of specific progenitor cells in embryos
Official title: Molecular and Cell Biology of Neuromesodermal Progenitors
Funded at State University New York Stony Brook · NIH-11051142 · Data updated 2026-11-12
This study is looking at special cells in developing embryos that help create the spinal cord and muscles, to understand how they decide what to become and how this knowledge could help improve ways to grow tissues for medical use.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $390,258 |
| NIH project number | 5R35GM150290-03 |
| Project ID | NIH-11051142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions related to spinal cord or muscle development, as well as those interested in advancements in regenerative therapies.
✕Less likely to help
Patients with conditions unrelated to developmental biology or those not seeking regenerative therapies may not receive direct benefits from this research.
What this research studies
This research investigates neuromesodermal progenitors (NMPs), which are crucial cells in vertebrate embryos that help form the spinal cord and skeletal muscle. The project aims to explore how these cells make decisions about their development and how they can be used to model cellular mechanisms in living organisms. By studying the interactions of specific proteins like Sox2 and Wnt, the research seeks to uncover important biological pathways that influence cell behavior and differentiation. This work could lead to advancements in tissue generation techniques and a better understanding of developmental biology.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of developmental processes and lead to improved strategies for tissue engineering and regenerative medicine.
How similar studies have gone: Previous research has shown promising results in understanding progenitor cells and their roles in development, indicating that this approach has potential for significant discoveries.
Where this research is happening
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State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Martin, Benjamin L — State University New York Stony Brook
- Study coordinator: Martin, Benjamin L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.