Understanding the biology of pediatric acute myeloid leukemia (AML)
Official title: Integrated Systems Biology of Pediatric AML
Funded at University of Florida · NIH-10986995 · Data updated 2026-11-12
This study is looking at how certain genes and changes in them can affect how well children with acute myeloid leukemia (AML) respond to treatment, with the hope of finding better ways to help these young patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $665,466 |
| NIH project number | 5R01CA270120-03 |
| Project ID | NIH-10986995 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with acute myeloid leukemia.
✕Less likely to help
Patients with other types of leukemia or those who are not within the pediatric age range may not benefit from this research.
What this research studies
This research focuses on pediatric acute myeloid leukemia (AML), a rare and aggressive cancer affecting children. The team aims to uncover molecular factors that influence prognosis and treatment outcomes by analyzing genetic and epigenetic data from patients. They utilize advanced statistical methods to enhance the understanding of how these factors relate to survival rates and treatment responses. The findings could lead to improved treatment strategies and personalized therapies for young patients with AML.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and better survival rates for children diagnosed with AML.
How similar studies have gone: Previous research has shown promise in using genomic and epigenomic analysis to improve understanding and treatment of AML, indicating that this approach has potential for success.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Lamba, Jatinder K. — University of Florida
- Study coordinator: Lamba, Jatinder K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.