Understanding the biology and genetics behind cancer spread
Biology and genetics of metastatic disease
This study is looking at how certain tiny molecules and genes affect the way cancer spreads in the body, with the hope of finding new ways to treat cancer that has moved to other areas.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10903789 on NIH RePORTER |
What this research studies
This research investigates the molecular changes that lead to the spread of cancer, known as metastasis, which is a major cause of death in cancer patients. The team is exploring how specific microRNAs and genetic variants, particularly related to the ApoE protein, influence the ability of cancer cells to invade other tissues. By identifying these genetic factors, the research aims to uncover new pathways that could be targeted for therapy. The findings may lead to innovative treatments that specifically address the metastatic process in various cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with metastatic cancer, particularly those with melanoma or other cancers where ApoE signaling is implicated.
Not a fit: Patients with early-stage cancer that has not metastasized may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively target and reduce cancer metastasis, improving survival rates for patients with advanced cancer.
How similar studies have performed: Previous research has shown promise in targeting metastasis through genetic insights, indicating that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Tavazoie, Sohail F. — Rockefeller University
- Study coordinator: Tavazoie, Sohail F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.