Understanding the best ways to add medications for treating high blood pressure.
Official title: Real-world Evidence to Inform Decisions for Hypertension Treatment Escalation
Funded at Yale University · NIH-10904999 · Data updated 2026-11-12
This study is looking at how to help adults with high blood pressure who aren't getting good results from just one medication by exploring the benefits and safety of adding a second medicine that fits their unique needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 10, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $631,189 |
| NIH project number | 5R01HL169954-02 |
| Project ID | NIH-10904999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are currently being treated for hypertension but are not achieving adequate blood pressure control with a single medication.
✕Less likely to help
Patients who have well-controlled hypertension with their current treatment regimen may not benefit from this research.
What this research studies
This research investigates how to improve treatment for high blood pressure in adults who are not achieving adequate control with a single medication. It aims to gather real-world evidence to determine the effectiveness and safety of adding a second antihypertensive drug based on individual patient characteristics. By analyzing variations in treatment practices, the study seeks to provide better guidance for healthcare providers on which additional medications may work best for different patients. The ultimate goal is to enhance clinical guidelines and improve patient outcomes in hypertension management.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with high blood pressure.
How similar studies have gone: Other research has shown promise in using real-world evidence to inform treatment decisions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Lu, Yuan — Yale University
- Study coordinator: Lu, Yuan
Related research
Other NIH-funded projects on the same topics.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Coaching and Navigation by Community Health Workers via Telehealth for High-Risk Hypertension
A program using telehealth and community health workers to help adults with severe hypertension connect to primary care and follow practical, heart-healthy lifestyle tips.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Noninvasive portal pressure estimation using ultrasound-based subharmonic signals
A noninvasive ultrasound method to estimate portal vein pressure in adults with cirrhosis to help manage varices and ascites.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.