Understanding the ASH1L Gene in Leukemia
Molecular analysis of ASH1L
This project aims to understand how a specific gene called ASH1L works, especially its role in certain types of acute lymphoblastic leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10911798 on NIH RePORTER |
What this research studies
The ASH1L gene helps blood stem cells grow and survive, and it is often overactive in leukemias, particularly a type called MLL-rearranged acute lymphoblastic leukemia, which is associated with a poor outlook. This gene acts as a major methyltransferase, adding chemical tags to histone proteins that then activate other genes important for development. ASH1L contains special parts that can 'read' different states of these histone proteins. Researchers want to figure out exactly how these parts of ASH1L work together to attach to genes and activate them. By understanding these detailed molecular mechanisms, we hope to find new ways to target ASH1L in leukemia.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding a gene linked to acute lymphoblastic leukemia.
Not a fit: Patients without acute lymphoblastic leukemia or those whose leukemia is not linked to ASH1L may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new drug targets and improved treatments for patients with acute lymphoblastic leukemia, especially those with ASH1L overactivity.
How similar studies have performed: While previous work has identified ASH1L's role in leukemia, this project explores novel, detailed molecular mechanisms that are currently not well understood.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Kutateladze, Tatiana G — University of Colorado Denver
- Study coordinator: Kutateladze, Tatiana G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.