Understanding the APOL1 Gene in Kidney Transplant Outcomes
3/14 ApoL1 Long-Term Kidney Transplantation Outcomes Network (Apollo) Clinical Center
['FUNDING_U01'] · JOHNS HOPKINS UNIVERSITY · NIH-11143108
This project helps us learn how a specific gene, APOL1, affects kidney transplant success and the health of living kidney donors, especially in people of African ancestry.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11143108 on ClinicalTrials.gov |
What this research studies
This project looks at how a gene called APOL1, common in people of Western Sub-Saharan African ancestry, affects kidney health after a transplant. Researchers are collecting information from kidney transplant recipients across the United States who received a kidney from a donor of African ancestry. They are also following living kidney donors of African ancestry to understand their long-term kidney health. The goal is to see how the APOL1 gene influences how well the transplanted kidney works over time and the risk of kidney problems for living donors.
Who could benefit from this research
Good fit: Ideal candidates for this research include kidney transplant recipients who received a kidney from a donor of African ancestry, and living kidney donors of African ancestry.
Not a fit: Patients who have not undergone a kidney transplant or are not of African ancestry may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to match donors and recipients, improve long-term outcomes for kidney transplant patients, and provide important health information for living kidney donors.
How similar studies have performed: This consortium builds upon existing knowledge about APOL1's association with kidney disease, expanding the scope to long-term transplant outcomes and living donor health.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRENNAN, DANIEL CONLON — JOHNS HOPKINS UNIVERSITY
- Study coordinator: BRENNAN, DANIEL CONLON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.