Understanding the APOL1 Gene and Long-Term Kidney Transplant Success
12/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11127752
This project looks at how a gene called APOL1 might affect the long-term success of kidney transplants for both recipients and donors.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11127752 on ClinicalTrials.gov |
What this research studies
We are part of a large effort called APOLLO, which is collecting information from kidney transplant recipients and donors. Our goal is to understand if specific changes in the APOL1 gene can increase the risk of a transplanted kidney failing over time. We carefully gather clinical details from medical records and collect DNA samples from participants at several West Coast medical centers. By following these individuals for many years, we hope to learn more about how genetics influence transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this type of research are kidney transplant recipients and kidney donors, particularly those of African ancestry who may carry the APOL1 gene mutations.
Not a fit: Patients not involved in kidney transplantation or those without the specific genetic factors being studied would not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could help doctors better predict kidney transplant outcomes and develop personalized care plans for patients, especially those with the APOL1 gene.
How similar studies have performed: This is described as the largest observational study of its kind, building upon existing knowledge to expand our understanding of APOL1's role in kidney transplantation.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HSU, CHI-YUAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: HSU, CHI-YUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.