Understanding the adenosine pathway in SIV, a model for HIV
Probing the role of adenosine pathway in SIV pathogenesis
This research explores how a natural body chemical called adenosine helps control gut inflammation in SIV infection, which can teach us about HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11357828 on NIH RePORTER |
What this research studies
Our bodies produce adenosine, a natural substance that helps calm inflammation and protect tissues. In SIV infection, which is similar to HIV in humans, we've observed that animals with severe gut problems have lower levels of adenosine in their gut. This suggests that adenosine might play a key role in preventing gut damage and inflammation related to the virus. This project aims to directly test if the adenosine pathway is crucial for managing gut issues in SIV/HIV.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but it is highly relevant to individuals living with HIV/AIDS, especially those experiencing gut-related complications.
Not a fit: Patients without HIV/AIDS or related immune conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to manage or prevent gut inflammation and dysfunction in people living with HIV.
How similar studies have performed: Previous studies in non-human primates have already shown differences in adenosine levels and inflammatory responses, supporting the importance of this pathway.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Vasile Pandrea, Ivona — University of Pittsburgh at Pittsburgh
- Study coordinator: Vasile Pandrea, Ivona
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.