Understanding the 4D structure of mammalian embryonic development
UW 4-Dimensional Genomic Organization of Mammalian Embryogenesis Center
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-10886047
This study is looking at how the way our genes are organized in 3D space affects how baby mice develop, helping scientists learn more about normal and abnormal growth in embryos.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10886047 on ClinicalTrials.gov |
What this research studies
This research investigates how the 4D structure of the genome influences the development of mammalian embryos, particularly using mice as a model organism. By employing advanced techniques like single-cell profiling and visual cell sorting, the project aims to create a detailed atlas of nuclear organization and gene expression changes throughout embryogenesis. This comprehensive dataset will help researchers understand the dynamic processes that shape various cell types during development, providing insights into both normal and abnormal embryonic growth.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or developmental abnormalities linked to chromosomal structure.
Not a fit: Patients with fully developed and healthy genomes or those not affected by developmental issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding developmental disorders and cancers related to genomic organization.
How similar studies have performed: Other research has shown promising results in understanding genomic organization, but this approach focusing on in vivo mammalian development is relatively novel.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOBLE, WILLIAM STAFFORD — UNIVERSITY OF WASHINGTON
- Study coordinator: NOBLE, WILLIAM STAFFORD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.