Understanding the 3D structures of genomes in individual cells
Advanced algorithms to infer and analyze 3D genome structures
This study is looking at how the way DNA is organized in our cells affects how genes work, which could help us understand diseases like cancer better, and it's designed for anyone interested in the science behind gene regulation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami Coral Gables NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10911301 on NIH RePORTER |
What this research studies
This research focuses on improving our understanding of how the 3D structures of genomes in individual cells influence gene regulation. By developing advanced algorithms, the project aims to analyze the spatial organization of DNA within cells, which is crucial for understanding how genes are turned on or off. The researchers will investigate the role of long non-coding RNAs and other elements in shaping these structures, which could lead to insights into various diseases, including cancers. The approach combines cutting-edge bioinformatics with experimental techniques to achieve high-resolution insights into genome architecture.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers that may be influenced by epigenetic changes and genome structure.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by epigenetic mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic regulation and the development of targeted therapies for diseases like cancer.
How similar studies have performed: Previous research using population Hi-C techniques has shown promise, but this project aims to explore untested aspects of individual cell genome structures.
Where this research is happening
Coral Gables, United States
- University of Miami Coral Gables — Coral Gables, United States (Active)
Researchers
- Principal investigator: Wang, Zheng — University of Miami Coral Gables
- Study coordinator: Wang, Zheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.