Understanding the 3D structure of the human genome and its role in diseases
Center for 3D Structure and Physics of the Genome
This study is looking at how the way our DNA is organized in our cells can influence how our genes work and stay stable, which could help us understand diseases like cancer and how we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10866485 on NIH RePORTER |
What this research studies
This research investigates how the three-dimensional organization of the human genome within the cell nucleus affects gene regulation and genome stability. By creating detailed maps of the genome's 4D structure, the project aims to uncover the molecular mechanisms behind chromosome folding and how these processes change during development and aging. The research employs advanced technologies to visualize and analyze the genome's structure, which could lead to insights into diseases like cancer and aging-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions, cancers, or those experiencing premature aging.
Not a fit: Patients with stable, non-genetic conditions or those not affected by genomic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases associated with genomic instability, such as cancer.
How similar studies have performed: Other research has shown promising results in understanding genome structure and its implications for diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Dekker, Job — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Dekker, Job
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.