Understanding the 3D structure of the human cerebellar cortex
Elucidating the Three-Dimensional Organization of the Human Cerebellar Cortex Using Histological and Ultra-High Resolution Structural MRI Approaches
This study is looking at the detailed structure of the brain's cerebellum to better understand how it works and how it might be affected by conditions like Alzheimer's and autism, using advanced imaging techniques and tissue samples.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11081815 on NIH RePORTER |
What this research studies
This research aims to explore the three-dimensional organization of the human cerebellar cortex using advanced techniques like 3D histology and ultra-high resolution structural MRI. By examining tissue samples, the study will relate the intricate 3D structures observed in high-resolution MRI scans to the actual anatomical organization of the cerebellar cortex. This could provide insights into how different parts of the cerebellum function and how they may be affected by various diseases. The findings may help improve our understanding of conditions like Alzheimer's disease and autism spectrum disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or autism spectrum disorders.
Not a fit: Patients with conditions unrelated to cerebellar function or those without neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic and therapeutic strategies for neurological conditions affecting the cerebellum.
How similar studies have performed: While there has been significant research on animal models, this approach to studying the human cerebellar cortex is relatively novel and untested.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Rushmore, Richard Jarrett — Boston University Medical Campus
- Study coordinator: Rushmore, Richard Jarrett
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.