Understanding the 3D structure of genomes in individual cells
Computational methods for studying single-cell 3D genome
This study is exploring how the DNA inside our cells is arranged in 3D, which is important for understanding how our genes work, and it's designed for scientists who want to learn more about how different types of cells function in our bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11014963 on NIH RePORTER |
What this research studies
This research focuses on the three-dimensional organization of genomes within individual cells, which is crucial for understanding how genes function. By utilizing advanced single-cell Hi-C technologies, the project aims to develop new computational tools that can analyze complex genomic data at a single-cell level. These tools will help identify and visualize the intricate 3D genome features and their connections to cellular functions, providing insights into how different cell types behave in various tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve complex cellular behaviors, such as cancer or genetic disorders.
Not a fit: Patients with stable, non-complex conditions that do not involve significant cellular variability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic functions and diseases at the cellular level, potentially improving personalized medicine approaches.
How similar studies have performed: While the approach of analyzing single-cell 3D genome structures is relatively novel, similar methodologies in genomic studies have shown promising results in understanding cellular functions.
Where this research is happening
Pittsburgh, United States
- Carnegie-Mellon University — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ma, Jian — Carnegie-Mellon University
- Study coordinator: Ma, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.