Understanding Tfh13 cells that cause severe allergic reactions
Generation & Regulation of Tfh13 cells that drive Pathogenic IgE in Allergy
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11027722
This study is looking at a special type of immune cell that helps create the antibodies responsible for serious allergic reactions, especially in kids with food and environmental allergies, to find new ways to prevent or lessen these reactions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11027722 on ClinicalTrials.gov |
What this research studies
This research investigates a specific type of immune cell, Tfh13 cells, which play a crucial role in the production of harmful IgE antibodies that lead to severe allergic reactions, including anaphylaxis. The study aims to uncover how these cells differentiate during allergic sensitization, particularly in children with food and environmental allergies. By examining the mechanisms behind Tfh13 cell development, the research seeks to identify potential targets for new treatments that could prevent or mitigate allergic responses. Patients may be involved in providing samples or data to help understand these processes better.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who suffer from food or environmental allergies.
Not a fit: Patients who do not have allergies or are over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the risk of severe allergic reactions in children.
How similar studies have performed: Previous research has shown success in understanding immune responses in allergies, but the specific focus on Tfh13 cells is relatively novel.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UTHAMAN, GOWTHAMAN — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: UTHAMAN, GOWTHAMAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease