Understanding Tendon-to-Bone Healing After Rotator Cuff Tears
Mechanisms of Primary Cilia Regulating Tendon Enthesis Development and Regeneration
This research explores how the body naturally heals the connection between tendon and bone, especially after common injuries like rotator cuff tears.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11123154 on NIH RePORTER |
What this research studies
Many people over 60 experience rotator cuff tears, and current treatments often lead to scar tissue and poor healing at the tendon-to-bone connection. We don't fully understand why this happens or how to improve healing. This project looks at tiny structures called primary cilia, which act like antennas on cells, to see how they respond to forces and signals in the body. By learning how these cilia work during healing, we hope to find new ways to help tendons repair themselves better.
Who could benefit from this research
Good fit: This foundational research is relevant to adults, particularly those over 60, who experience rotator cuff tears and face challenges with healing.
Not a fit: Patients will not receive direct treatment or immediate benefit from this basic science research, as it focuses on understanding fundamental biological processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent scar tissue formation and improve the long-term success of rotator cuff tear repairs.
How similar studies have performed: This project builds upon previous work indicating the importance of primary cilia in healing, suggesting a promising avenue for further exploration.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Iatridis, James C. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Iatridis, James C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.