Understanding tendon damage and cellular responses in a model of tendinosis
Multiscale tendon damage and aberrant cellular responses in an in vivo model of tendinosis
This study looks at how too much strain on tendons can lead to long-lasting pain from tendinosis, and it aims to understand the damage this causes and how it affects the body's cells, with the hope of finding better ways to help people who are dealing with this tough condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10891496 on NIH RePORTER |
What this research studies
This research investigates how tendon overuse leads to chronic tendinosis, a condition that causes pain and is difficult to treat. Using a preclinical animal model, the study examines the structural and mechanical damage in tendons and how this damage affects cellular responses. By analyzing the mechanisms involved in tendinosis, the research aims to uncover the relationship between mechanical overload and cellular signaling, which could provide insights into better treatment options for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic tendon pain or tendinosis, particularly those with a history of tendon overuse.
Not a fit: Patients with acute tendon injuries or those not experiencing chronic tendon pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic tendinosis, reducing pain and enhancing recovery for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding tendon mechanics and cellular responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- University of Delaware — Newark, United States (Active)
Researchers
- Principal investigator: Elliott, Dawn M — University of Delaware
- Study coordinator: Elliott, Dawn M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.