Understanding Telomeres and Telomerase
Structure and Dynamics of Telomeres and Telomerase
This project explores how special structures at the ends of our chromosomes, called telomeres, and an enzyme called telomerase work to protect our genetic information, which is important for understanding diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-11124062 on NIH RePORTER |
What this research studies
Our bodies have tiny protective caps called telomeres on the ends of our chromosomes, which are like shoelace tips that keep our genetic material safe. An enzyme called telomerase helps maintain the length of these telomeres, preventing them from getting too short as our cells divide. When telomeres become too short, cells can stop growing or even die, and problems with this system are linked to serious conditions like cancer. This work aims to uncover the detailed ways telomeres and telomerase function at a molecular level. By understanding these fundamental processes, we hope to find new ways to address diseases where telomere health is disrupted.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but aims to benefit individuals with cancers and rare genetic syndromes where telomere dysfunction plays a role.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this fundamental understanding could lead to new strategies for treating cancers and other diseases linked to telomere problems.
How similar studies have performed: This project builds upon previous findings from this and other laboratories, advancing detailed models of telomerase and telomere biology.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Stone, Michael D — University of California Santa Cruz
- Study coordinator: Stone, Michael D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.