Understanding TCF20's Role in Autism and Related Neurodevelopmental Disorders
The role of Tcf20 in activity-dependent inhibitory signaling and autism spectrum disorder pathogenesis
This project explores how a gene called TCF20 contributes to autism spectrum disorder and a related condition called TAND, hoping to uncover new ways to help children with these challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11158911 on NIH RePORTER |
What this research studies
This research focuses on TCF20-associated neurodevelopmental disorder (TAND), a condition caused by mutations in the TCF20 gene, which leads to symptoms like autism spectrum disorder (ASD), intellectual disability, and seizures. We aim to understand the specific molecular and brain pathways that cause these problems. Using advanced neuroscience techniques and special mouse models, we will investigate how TCF20 regulates brain signaling, particularly after development. The goal is to discover if TCF20's function in activity-dependent pathways contributes to TAND symptoms, which could reveal new targets for treatments.
Who could benefit from this research
Good fit: Patients with TCF20-associated neurodevelopmental disorder (TAND) or autism spectrum disorder (ASD) could potentially benefit from future therapies developed from this foundational research.
Not a fit: Patients whose neurodevelopmental disorders are not linked to the TCF20 gene may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of TAND and ASD, potentially identifying new targets for future treatments to improve symptoms.
How similar studies have performed: While the genetic basis of TAND is known, the specific disease mechanisms and reversibility are not, making this a novel exploration into TCF20's post-developmental function.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Zhou, Jian — Emory University
- Study coordinator: Zhou, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.