Understanding Takotsubo Syndrome
Official title: Mechanisms Underlying Takotsubo Syndrome
Funded at Northeast Ohio Medical University · NIH-11127516 · Data updated 2026-11-12
This project explores how changes in blood flow to the heart's tip might cause Takotsubo Syndrome, a temporary heart condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $574,647 |
| NIH project number | 5R01HL161512-04 |
| Project ID | NIH-11127516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have experienced or are at risk for Takotsubo Syndrome might find this research relevant to their condition.
✕Less likely to help
Patients with heart conditions unrelated to Takotsubo Syndrome or its specific mechanisms of blood flow regulation may not directly benefit from this particular research.
What this research studies
We are looking into whether specific blood flow issues in the lower part of the heart lead to Takotsubo Syndrome. Our idea is that a slight reduction in blood flow causes the heart muscle to go into a "hibernation" state, where it slows down its function to protect itself from damage. This temporary slowdown helps the heart match its reduced blood supply, preventing permanent injury. We also want to see if improving blood flow to this area can help people with Takotsubo Syndrome.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of Takotsubo Syndrome and potentially new ways to prevent or treat it by targeting blood flow.
How similar studies have gone: This research proposes a novel hypothesis regarding the cause of Takotsubo Syndrome, building on existing knowledge but exploring a new mechanism.
Where this research is happening
-
Northeast Ohio Medical University
Rootstown, United States Active
Researchers
- Principal investigator: Chilian, William M — Northeast Ohio Medical University
- Study coordinator: Chilian, William M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.