Understanding T lymphopenia in heart failure after a heart attack
T Lymphopenia in Ischemic Heart Failure
This study looks at how a drop in certain immune cells called T lymphocytes after a heart attack affects heart health, using mice to find out how this happens and what we can do to help improve heart recovery, which could lead to new treatments for people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10880433 on NIH RePORTER |
What this research studies
This research investigates how a decrease in T lymphocytes, a type of immune cell, occurs after a heart attack and its impact on heart function. The study uses a mouse model to explore the mechanisms behind T lymphopenia and its potential role in worsening heart failure. By examining how T cells are redistributed and their development is impaired, the research aims to identify new therapeutic strategies to improve heart repair and function post-heart attack. Patients may benefit from insights that could lead to innovative treatments targeting immune responses in heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an acute myocardial infarction and are at risk of developing chronic heart failure.
Not a fit: Patients who have not had a heart attack or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart recovery and outcomes for patients who have suffered a heart attack.
How similar studies have performed: Previous research has shown that targeting immune cell responses can improve outcomes in heart failure, suggesting that this approach may hold promise.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Ma, Yonggang — University of South Florida
- Study coordinator: Ma, Yonggang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.