Understanding T cells' role in pregnancy complications
Function of T cells at the Maternal-Fetal Interface
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11244662
This study is looking at how certain immune cells work in the placenta during pregnancy to understand why some babies are born too early, with the hope of finding ways to help prevent preterm births and keep both moms and babies healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11244662 on ClinicalTrials.gov |
What this research studies
This research investigates how T cells function at the maternal-fetal interface, particularly in the context of preterm birth (PTB). By examining the immune response and inflammation in the placenta, the study aims to uncover the underlying mechanisms that lead to complications during pregnancy. The researchers will utilize advanced techniques to analyze human tissue samples and animal models, focusing on the role of immune cells in placental health and disease. This work could provide insights into preventing preterm births and improving outcomes for mothers and infants.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals at risk of preterm birth or those who have experienced complications during pregnancy.
Not a fit: Patients who are not pregnant or those with pregnancies that are not at risk for preterm birth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing preterm birth and improving maternal and infant health.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in pregnancy, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KONNIKOVA, LIZA — YALE UNIVERSITY
- Study coordinator: KONNIKOVA, LIZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.