Understanding T cell roles in Frontotemporal dementia
Identifying T cell determinants of heritable Frontotemporal dementia
This study is looking at how certain immune cells called T cells might play a role in Frontotemporal dementia and Alzheimer's disease, especially for people with a specific genetic change, and it hopes to find ways to help these immune cells work better to improve health outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11055376 on NIH RePORTER |
What this research studies
This research investigates how T cell dysfunction and the balance of T cell subsets contribute to Frontotemporal dementia (FTD) and Alzheimer's disease. The study aims to explore the interaction between environmental signals, such as those from the gut microbiome, and genetic factors that affect T cell function and disease progression. By focusing on the common C9ORF72 mutation associated with FTD, the research seeks to identify potential strategies to stabilize beneficial T regulatory cells and reduce harmful pro-inflammatory cells, which could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Frontotemporal dementia or those carrying the C9ORF72 mutation.
Not a fit: Patients with other forms of dementia not related to Frontotemporal dementia or the C9ORF72 mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventative strategies and treatments for Frontotemporal dementia and related disorders.
How similar studies have performed: Other research has shown promising results in understanding T cell roles in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Burberry, Aaron — Case Western Reserve University
- Study coordinator: Burberry, Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.