Understanding T cell roles in food allergies
Heterogeneity of T cell phenotype and function in food allergy
This study is looking at how different types of immune cells, called T cells, help produce IgE, which is important in food allergies, especially in kids, to find new ways to treat these allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10824382 on NIH RePORTER |
What this research studies
This research investigates the complex roles of different T cell types in the maintenance of IgE, a key factor in food allergies, particularly in children. By examining the cellular mechanisms that contribute to IgE production, the study aims to identify how specific T cells interact with B cells to produce allergen-specific IgE. The research utilizes advanced techniques like flow cytometry to analyze T cell populations and their functions in individuals with food allergies. This could lead to insights into potential new treatments for food allergies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who have been diagnosed with IgE-mediated food allergies.
Not a fit: Patients who do not have food allergies or are older than 21 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for food allergies, improving the quality of life for affected children.
How similar studies have performed: Previous research has shown promising results in understanding T cell roles in allergies, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Berin, Cecilia — Northwestern University at Chicago
- Study coordinator: Berin, Cecilia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.