Understanding T-cell responses in long COVID patients
Official title: Modeling the dynamics and composition of T-cell receptor repertoires in post-acute sequelae of COVID-19 (PASC)
Funded at Institute for Systems Biology · NIH-11001955 · Data updated 2026-11-12
This study is looking at how the immune system's T-cells behave in people with long COVID compared to those who had COVID-19 without long-term effects and healthy individuals, to help us better understand what happens in the body after recovering from the virus.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | December 18, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $91,180 |
| NIH project number | 5R03AI175977-02 |
| Project ID | NIH-11001955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced long COVID symptoms following a COVID-19 infection.
✕Less likely to help
Patients who have not had COVID-19 or do not exhibit long COVID symptoms may not benefit from this research.
What this research studies
This research investigates the immune system's T-cell receptor dynamics in patients experiencing post-acute sequelae of COVID-19, commonly known as long COVID. By analyzing existing data from previous studies, the researchers will compare the immune responses of long COVID patients to those of COVID-19 patients without long COVID and healthy individuals. The study employs advanced statistical, biophysical, and machine learning techniques to identify specific T-cell receptor features associated with long COVID. This comprehensive approach aims to uncover the underlying mechanisms of long COVID and improve understanding of its effects on the immune system.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for long COVID, improving the quality of life for affected patients.
How similar studies have gone: Other research has shown promising results in understanding immune responses in COVID-19, making this approach both relevant and potentially impactful.
Where this research is happening
-
Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Hadlock, Jennifer — Institute for Systems Biology
- Study coordinator: Hadlock, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.