Understanding T-cell Loss in Heart Failure After a Heart Attack
T Lymphopenia in Ischemic Heart Failure
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-11124215
This project explores why some people lose important immune cells called T-cells after a heart attack and if restoring these cells could help their hearts recover.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11124215 on ClinicalTrials.gov |
What this research studies
Heart failure after a heart attack is a major health concern, and a decrease in T-cells, a type of immune cell, is often linked to worse outcomes. We believe this T-cell loss might occur because these cells move from the blood to the bone marrow or because the body struggles to make new T-cells. Our goal is to uncover the exact reasons behind this T-cell reduction following a heart attack. We are also investigating if preventing this T-cell loss could be a new way to help the heart heal and improve long-term health.
Who could benefit from this research
Good fit: This foundational research is for patients interested in the underlying causes of heart failure after a heart attack and potential future immune-based therapies.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that improve heart recovery and long-term health for patients who have had a heart attack.
How similar studies have performed: The link between T lymphopenia and worse outcomes in MI patients is consistently observed, but the mechanisms and therapeutic potential are largely unknown, making this a novel area of investigation.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MA, YONGGANG — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: MA, YONGGANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.