Understanding T Cell Functions and Their Genetic Profiles
Microscale System for Functional T Cell Transcriptomics
This study is looking at how T cells, which are important for fighting off illnesses, work and how their genes affect their behavior, especially in conditions like chronic lymphocytic leukemia, to help develop better treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10319619 on NIH RePORTER |
What this research studies
This research investigates how T cells, which play a crucial role in the immune system, function and how their activities are linked to their genetic makeup. By using advanced microscopy techniques and single-cell RNA sequencing, the study aims to analyze individual T cells' behaviors, such as their movement and interactions with other cells. This approach could provide insights into how T cells respond in diseases like chronic lymphocytic leukemia, potentially leading to better-targeted therapies. The goal is to create a new platform that can analyze many cells simultaneously, which is currently not possible with existing technologies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with chronic lymphocytic leukemia or other related malignancies.
Not a fit: Patients with non-cancerous conditions or those not affected by immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with cancers and immune disorders.
How similar studies have performed: Other research has shown promise in using single-cell analysis to understand cellular functions, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Kam, Lance C — Columbia University Health Sciences
- Study coordinator: Kam, Lance C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.