Understanding T-cell Function for Immunity Against Viruses and Cancer
CTCF in CD8 T cell homeostasis and anti-viral/tumor immunity
['FUNDING_R01'] · HACKENSACK UNIVERSITY MEDICAL CENTER · NIH-11142982
This project looks at how special immune cells called CD8 T cells work to protect us from viruses and cancer, hoping to improve future treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HACKENSACK UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (HACKENSACK, UNITED STATES) |
| Trial ID | NIH-11142982 on ClinicalTrials.gov |
What this research studies
Our immune system relies on CD8 T cells to fight off infections and cancer. This work aims to understand the tiny molecular details of how these T cells grow, stay balanced, and learn to remember past threats. We are exploring how the 3D structure of a cell's genetic material helps control these T cells, which is a new area of focus. By uncovering these fundamental mechanisms, we hope to find new ways to make T cells more effective at fighting disease. This knowledge could lead to better vaccines and immunotherapies for patients.
Who could benefit from this research
Good fit: Patients with viral infections or cancer who might benefit from improved T-cell based therapies could be ideal candidates for future treatments stemming from this research.
Not a fit: Patients whose conditions are not related to CD8 T cell function or who do not respond to T-cell based immunotherapies may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to more effective vaccines and new or improved immunotherapies for viral infections and various cancers.
How similar studies have performed: Adoptive cell therapies, including CAR T cells, have shown promising results in treating certain cancers, suggesting that enhancing T cell function holds significant therapeutic potential.
Where this research is happening
HACKENSACK, UNITED STATES
- HACKENSACK UNIVERSITY MEDICAL CENTER — HACKENSACK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XUE, HAI-HUI — HACKENSACK UNIVERSITY MEDICAL CENTER
- Study coordinator: XUE, HAI-HUI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.