Understanding Synapse Loss in Alzheimer's Disease
mGluR5 and Phase State Dependent Synaptic Loss in Alzheimer's Disease
This work explores how brain cells lose connections in Alzheimer's disease and tests a new compound that might protect these connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11134688 on NIH RePORTER |
What this research studies
Alzheimer's disease causes brain cells to lose their connections, called synapses, which is a key reason why memory and thinking abilities decline. We are looking into the specific molecular reasons behind this synapse loss, focusing on a protein called mGluR5. Our previous work showed that mGluR5 plays a crucial role in synapse problems and memory issues, and we've found a new compound that can block this process. We are now working to understand how this compound interacts with different brain cells and pathways, and how mGluR5 is regulated in Alzheimer's disease, using advanced imaging and cellular models.
Who could benefit from this research
Good fit: This foundational research is for individuals interested in the underlying causes of Alzheimer's disease and future therapeutic developments.
Not a fit: Patients seeking immediate treatment options or direct clinical trial participation would not directly benefit from this basic science grant.
Why it matters
Potential benefit: If successful, this work could lead to a new treatment that protects brain synapses and slows or stops the progression of Alzheimer's disease.
How similar studies have performed: Previous work by this team has demonstrated the essential role of mGluR5 in synapse dysfunction and memory deficits, suggesting a promising direction for this research.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Strittmatter, Stephen M — Yale University
- Study coordinator: Strittmatter, Stephen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.