Understanding swallowing and airway function in sporadic inclusion body myositis
Profiling Upper Aerodigestive Functioning in Sporadic Inclusion Body Myositis
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10997659
This study is looking at how sporadic inclusion body myositis affects swallowing and breathing functions, especially since problems with swallowing can lead to serious issues like pneumonia, and it's for people with this condition to help understand their challenges better.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10997659 on ClinicalTrials.gov |
What this research studies
This research investigates how sporadic inclusion body myositis (IBM) affects upper aerodigestive functions, particularly swallowing and airway clearance. It aims to identify the mechanisms behind swallowing impairments, known as dysphagia, which significantly contribute to early mortality in IBM patients due to aspiration pneumonia. By utilizing the Modified Barium Swallow Impairment Profile (MBSImP), the study will analyze swallowing physiology in patients with IBM compared to healthy individuals. Additionally, it will explore airway clearance abilities, which are crucial for preventing aspiration-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sporadic inclusion body myositis who experience swallowing difficulties.
Not a fit: Patients with other forms of myositis or those without swallowing impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and management strategies for patients with sporadic inclusion body myositis, enhancing their quality of life and reducing mortality risk.
How similar studies have performed: Previous research has shown success in using similar methodologies to assess swallowing dysfunction in other neurological disorders, indicating potential for meaningful insights in this study.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AMBROCIO, KEVIN RENZ — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: AMBROCIO, KEVIN RENZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.