Understanding swallowing and airway function in sporadic inclusion body myositis
Official title: Profiling Upper Aerodigestive Functioning in Sporadic Inclusion Body Myositis
Funded at University of Pittsburgh at Pittsburgh · NIH-10997659 · Data updated 2026-11-12
This study is looking at how sporadic inclusion body myositis affects swallowing and breathing functions, especially since problems with swallowing can lead to serious issues like pneumonia, and it's for people with this condition to help understand their challenges better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL176098-01 |
| Project ID | NIH-10997659 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sporadic inclusion body myositis who experience swallowing difficulties.
✕Less likely to help
Patients with other forms of myositis or those without swallowing impairments may not benefit from this research.
What this research studies
This research investigates how sporadic inclusion body myositis (IBM) affects upper aerodigestive functions, particularly swallowing and airway clearance. It aims to identify the mechanisms behind swallowing impairments, known as dysphagia, which significantly contribute to early mortality in IBM patients due to aspiration pneumonia. By utilizing the Modified Barium Swallow Impairment Profile (MBSImP), the study will analyze swallowing physiology in patients with IBM compared to healthy individuals. Additionally, it will explore airway clearance abilities, which are crucial for preventing aspiration-related complications.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and management strategies for patients with sporadic inclusion body myositis, enhancing their quality of life and reducing mortality risk.
How similar studies have gone: Previous research has shown success in using similar methodologies to assess swallowing dysfunction in other neurological disorders, indicating potential for meaningful insights in this study.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Ambrocio, Kevin Renz — University of Pittsburgh at Pittsburgh
- Study coordinator: Ambrocio, Kevin Renz
Related research
Other NIH-funded projects on the same topics.
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Myositis-ILD Risk Prediction: How ILD Progresses in Myositis Patients
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-
Autoantibodies and membrane repair in myositis
A blood and tissue study seeks to understand how immune reactions against muscle repair proteins contribute to inflammatory myositis, with the goal of guiding better treatments for people with this condition.
-
Why chikungunya causes long-lasting joint and muscle pain
This work looks at how chikungunya virus can linger in joint and muscle cells and keep causing pain for people who had the infection.
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Autoantibodies against muscle membrane repair proteins in myositis
This work looks at whether people with myositis have antibodies that attack proteins that fix damaged muscle cell membranes and how that may cause muscle inflammation and weakness.
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Predicting lung disease outcomes in people with myositis
This project combines medical information and genetic markers to predict which people with myositis will have worsening interstitial lung disease.
-
Cancer risk in inflammatory muscle disease (myositis)
This project looks for signs in people with idiopathic inflammatory myopathies that show whether they have or might develop cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.