NIH-funded research R01 grant

Understanding suicide risk in adolescent girls during their menstrual cycle

Official title: Adolescent Girls’ Risk for Suicide Across the Menstrual Cycle: Examining Stress and Negative Valence Systems Longitudinally

Funded at Univ of North Carolina Chapel Hill · NIH-11018611 · Data updated 2026-11-12

This study is looking at how different stages of the menstrual cycle might influence suicidal thoughts and feelings in teenage girls, so we can better understand when they might be at greater risk and help support their mental health.

More Suicide research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniv of North Carolina Chapel Hill
NIH-funded
Lab location1 site (Chapel Hill, United States)
Project startApril 1, 2020
Project endJanuary 31, 2026
Funding year2025
Award (this year)$599,937
NIH project number5R01MH122446-05
Project IDNIH-11018611 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adolescent girls aged 12 to 20 who may experience suicidal thoughts or behaviors.

Less likely to help

Patients who are not within the adolescent age range or who do not experience any mental health issues may not benefit from this research.

What this research studies

This research investigates how the menstrual cycle affects the risk of suicidal thoughts and behaviors in adolescent girls. By examining stress responses and hormonal changes throughout different phases of the menstrual cycle, the study aims to identify specific times when girls may be at higher risk for these thoughts and behaviors. Participants will report their experiences and symptoms, allowing researchers to analyze the relationship between hormonal fluctuations, stress, and mental health outcomes. The goal is to better understand the underlying factors contributing to increased suicide risk in this population.

Why it matters

Potential benefit: If successful, this research could lead to improved prevention strategies and interventions for adolescent girls at risk of suicide.

How similar studies have gone: Previous research has shown that hormonal changes can influence mental health, but this specific focus on adolescent girls' menstrual cycles and suicide risk is relatively novel.

Where this research is happening

  • Univ of North Carolina Chapel Hill
    Chapel Hill, United States
    Active

Researchers

  • Principal investigator: Girdler, Susan S. — Univ of North Carolina Chapel Hill
  • Study coordinator: Girdler, Susan S.

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.