Understanding sugar changes in Alzheimer's disease
Comprehensive Characterization of Glycosylation Alterations in Alzheimer's Disease
This study is looking at how changes in certain sugars in the body might help us find early signs of Alzheimer's disease, and we're inviting patients to share blood samples to help us discover these important clues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10445264 on NIH RePORTER |
What this research studies
This research investigates how changes in the sugars attached to proteins and lipids may contribute to Alzheimer's disease (AD). By analyzing blood samples, the study aims to identify early biomarkers that could indicate the onset of AD, particularly focusing on the role of the Apolipoprotein E (ApoE) protein, which is linked to increased risk for developing the disease. The research utilizes advanced techniques in glycobiology to explore these alterations and their potential implications for diagnosis and treatment. Patients may be involved in providing blood samples to help identify these biomarkers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those who are ApoE4 carriers.
Not a fit: Patients with advanced Alzheimer's disease or those without genetic risk factors for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment options for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in identifying biomarkers through glycosylation changes, suggesting that this approach may be effective.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Zivkovic, Angela M — University of California at Davis
- Study coordinator: Zivkovic, Angela M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.