Understanding Sudden Death Risk in Mitral Valve Prolapse
Sudden Death Risk Assessment and Mechanistic Insights in Arrhythmic Mitral Valve Prolapse Using Cardiac MRI and Circulating Proteomic Biomarkers
This project aims to find better ways to identify people with mitral valve prolapse who might be at higher risk for sudden cardiac arrest.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11184428 on NIH RePORTER |
What this research studies
We are looking closely at patients with mitral valve prolapse to understand the specific features and underlying causes linked to irregular heart rhythms. We will also explore a panel of blood markers, including both established and new tests, to see if they can help us easily and affordably find patients who have heart scarring and are at risk for sudden cardiac death. Our goal is to create a new model that can predict this risk more accurately, helping doctors protect patients with mitral valve prolapse.
Who could benefit from this research
Good fit: Ideal candidates for this work would be individuals diagnosed with mitral valve prolapse, particularly those with or at risk for arrhythmias.
Not a fit: Patients without mitral valve prolapse or those not at risk for arrhythmias would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier identification of patients with mitral valve prolapse who are at risk for sudden cardiac death, allowing for timely preventative care.
How similar studies have performed: While the link between mitral valve prolapse and sudden cardiac death has been observed, this project aims to develop novel, more precise risk assessment tools and mechanistic insights.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Shah, Dipan J. — Methodist Hospital Research Institute
- Study coordinator: Shah, Dipan J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.