Understanding subtypes and causes of early-onset Parkinson's
Early Onset Parkinson’s disease subtypes and pathogenic mechanisms
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11141907
This project looks at genes, inflammation, and alpha-synuclein in people who develop Parkinson's before age 50 to find meaningful subtypes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11141907 on ClinicalTrials.gov |
What this research studies
If you had Parkinson's before age 50, researchers will enroll a large group of patients to collect medical histories, genetic testing, and central and peripheral biosamples. The team will test for alpha-synuclein in samples like cerebrospinal fluid and blood and will measure inflammation markers across central and peripheral tissues. They will compare these results with people who developed Parkinson's later in life to look for distinct patterns. The investigators aim to group early-onset patients by the main biological causes behind their condition.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed with Parkinson's whose symptoms began before age 50 who can provide medical history and biosamples and attend study visits.
Not a fit: People whose Parkinson's began after age 50 or those seeking immediate new treatments may not directly benefit from this research right away.
Why it matters
Potential benefit: If successful, this work could help doctors classify early-onset Parkinson's into biological subtypes that support more personalized care and targeted future treatments.
How similar studies have performed: Prior research has linked genetics, inflammation, and alpha-synuclein to Parkinson's in general, but combining these measures to define subtypes in early-onset Parkinson's is a relatively new approach.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIBOLDI, GIULIETTA MARIA — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: RIBOLDI, GIULIETTA MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.