Understanding subtle cognitive decline in older adults
Official title: Heterogeneity of subtle cognitive decline phenotypes in community-dwelling older adults
Funded at University of California, San Diego · NIH-10713843 · Data updated 2026-11-12
This study is looking at the early signs of memory and thinking changes in older adults who aren't diagnosed with mild cognitive impairment yet, to help spot potential risks for Alzheimer's and similar conditions, so that families can get the support they need sooner.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,838,200 |
| NIH project number | 1RF1AG082726-01 |
| Project ID | NIH-10713843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are experiencing subtle cognitive difficulties but do not yet have a diagnosis of mild cognitive impairment.
✕Less likely to help
Patients with advanced Alzheimer's disease or those who do not exhibit any cognitive decline may not benefit from this research.
What this research studies
This research investigates the early signs of cognitive decline in older adults who do not yet meet the criteria for mild cognitive impairment. By analyzing existing data, the study aims to identify different patterns of cognitive changes that may indicate the onset of Alzheimer's disease and related dementias. The goal is to refine our understanding of these subtle changes, which could provide critical insights for early intervention and support for affected individuals and their families. The research employs a data-driven approach to explore cognitive heterogeneity and its implications for future care.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for Alzheimer's disease, improving the quality of life for patients and their families.
How similar studies have gone: Previous research has shown success in identifying cognitive subtypes in older adults, suggesting that this approach may yield valuable insights into early cognitive decline.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Thomas, Kelsey R — University of California, San Diego
- Study coordinator: Thomas, Kelsey R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.