Understanding Stomach Changes that Can Lead to Cancer
Induction and Evolution of Metaplasia in the Stomach
This research explores how certain stomach cells change and develop abnormal growths, which can sometimes lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11099876 on NIH RePORTER |
What this research studies
Our stomachs can sometimes develop abnormal cell changes, called metaplasia, especially when certain protective cells are lost or damaged. There are two main types of these changes: intestinal metaplasia, where intestinal-like cells appear in the stomach, and SPEM, where deep gland cells show up in unusual places. We are learning that SPEM often starts when regular stomach cells transform into mucus-producing cells, and this process is influenced by immune cells in the stomach lining. In ongoing damage and inflammation, the surrounding support cells, called fibroblasts, also change, potentially creating an environment that encourages these abnormal growths. By studying these cellular transformations in detail, we hope to better understand how they begin and progress.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals at risk for stomach metaplasia and related cancers.
Not a fit: Patients not at risk for stomach metaplasia or related conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to prevent or treat stomach conditions that increase the risk of cancer.
How similar studies have performed: Previous investigations have recognized the types of metaplasia and suggested mechanisms for their development, building a foundation for this work.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Goldenring, James Richard — Vanderbilt University Medical Center
- Study coordinator: Goldenring, James Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.