Understanding Stomach Changes in Obesity and Type 2 Diabetes
Mechanisms of Obesity-related Altered Stomach Plasticity
This research explores how obesity and type 2 diabetes cause changes in stomach cells that can lead to digestive problems.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11300792 on NIH RePORTER |
What this research studies
Many people with type 2 diabetes and obesity experience more digestive issues, including acid reflux and certain gastrointestinal cancers. This project aims to understand how the cells lining the stomach change in these conditions, which is crucial for developing new treatments. Researchers have observed that genes in the stomach are significantly altered during obesity, and while some hormone-producing cells increase, they may not function correctly. This work will specifically look at how obesity affects special 'progenitor' cells in the stomach that are responsible for creating new cells, exploring how body fat might disrupt their normal function.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but focuses on understanding cellular mechanisms relevant to individuals with obesity and type 2 diabetes who experience gastrointestinal issues.
Not a fit: Patients without obesity or type 2 diabetes, or those without related gastrointestinal conditions, would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to prevent or treat digestive diseases linked to obesity and type 2 diabetes.
How similar studies have performed: This project builds on preliminary findings by the researcher, suggesting a novel approach to understanding gastric cell changes in obesity.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Mckimpson, Wendy Marie — Emory University
- Study coordinator: Mckimpson, Wendy Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.