Understanding Stem Cells for Skin Healing in Aging
Stem Cell Integral Membrane Transporter ABCB5 and Dermal Regeneration
This work explores how special stem cells in our skin contribute to healing and how they might be used to improve skin repair as we age.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11112478 on NIH RePORTER |
What this research studies
This project aims to understand the role of specific stem cells, called ABCB5(+) dermal mesenchymal stem cells, in keeping our skin healthy and helping it heal. Researchers believe that a decrease in these stem cells might be why skin healing slows down as we get older. They will also explore if transplanting these special stem cells could help restore the skin's ability to heal wounds in older adults. This could lead to new ways to treat skin problems related to aging.
Who could benefit from this research
Good fit: This research is relevant for adults, particularly older adults, who experience challenges with skin healing and regeneration.
Not a fit: Patients who do not have skin healing issues or are not in the adult age range may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new stem cell therapies for improving skin healing and regeneration, especially for older adults with wounds.
How similar studies have performed: This research addresses fundamental questions in stem cell biology and aging that have not yet been fully explored in prospective studies, making it a novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Frank, Markus H. — Brigham and Women's Hospital
- Study coordinator: Frank, Markus H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.