Understanding stem cell roles in prostate cancer progression
A transdisciplinary approach for dissecting stem cell states in prostate cancer
This study is looking into how certain cells in prostate cancer help the disease grow and become harder to treat, with the goal of finding new ways to target and fight these stubborn cancer cells.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10915521 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind prostate cancer progression, focusing on cancer stem cells that contribute to tumor growth. By combining expertise from cancer biology and advanced computational methods, the team aims to identify and characterize these stem cells and their unique molecular signatures. The research will utilize genetically-engineered mouse models and human tumor samples to validate findings, particularly in cases of treatment-resistant prostate cancer. This approach seeks to develop targeted therapies that can effectively combat the malignancy sustained by these cancer stem cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with prostate cancer, especially those with treatment-resistant castration-resistant prostate cancer (CRPC).
Not a fit: Patients with early-stage prostate cancer or those not diagnosed with prostate cancer may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with advanced prostate cancer by targeting the cancer stem cells responsible for tumor growth.
How similar studies have performed: Other research has shown promise in targeting cancer stem cells in various cancers, suggesting that this approach could yield significant advancements in prostate cancer treatment.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Rabadan, Raul — Columbia University Health Sciences
- Study coordinator: Rabadan, Raul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.